Thursday, August 11, 2011
Blocking Receptor In Key Hormone Fires Up Enzyme To Kill Pancreatic Cancer Cells
Pancreatic cancer researchers at Thomas Jefferson University have shown, for the first time, that blocking a receptor of a key hormone in the renin-angiotensin system (RAS) reduces cancer cell growth by activating the enzyme AMPK to inhibit fatty acid synthase, the ingredients to support cell division. With that, a new chemopreventive agent that inhibits the angiotensin II type 2 receptor never before thought to play a role in tumor growth could be developed to help treat one of the fastest-moving cancers that has a 5-year survival rate of only 5 percent. Hwyda Arafat, M.D., Ph.D...
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