Heart Disease Results From High-Fat Diet And Lack Of Enzyme In Mice

It's no secret that a high-fat diet isn't healthy. Now researchers have discovered a molecular clue as to precisely why that is. Writing in the Journal of Biological Chemistry, Mitchell Lazar, MD, PhD, the Sylvan Eisman Professor of Medicine and director of the Institute for Diabetes, Obesity, and Metabolism at the Perelman School of Medicine at the University of Pennsylvania, and colleagues, describe that mice lacking a gene-expression-controlling enzyme fed a high-fat diet experience rapid thickening of the heart muscle and heart failure...

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